Product and Company Identification . Terms and Conditions Compliance Solutions Industries About 3E News & Events . Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). endobj
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if interested in purchasing or obtaining a sample for assessment, you should contact Dupont themselves directly. HAZARDS IDENTIFICATION EMERGENCY TELEPHONE NUMBERS (302) 451-0100 (FMC Plant - Newark, Delaware) (303) 595-9048 (Medical - U.S. - Call Collect) For leak, fire, spill, or accident emergencies, call: (800) 424-9300 (CHEMTREC - U.S.A. & Canada) (703) 527-3887 (CHEMTREC - Collect - All Other Countries) EMERGENCY OVERVIEW: Off-white, free-flowing, odorless powder. Catalog Number 102331. 1.3. 1 0 obj
Examination of urine, blood and faecal levels of vitamin B 1 during microcrystalline cellulose ingestion showed no difference from control periods (Anonymous, 1966). PharmaCentral 2021 . It is made from purified partially depolymerised Alfa cellulose relatively free from both organic and inorganic contaminants. Cellulose microcrystalline MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose . AFFINISOL hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement of poorly soluble drugs by maintaining stable solid dispersions and inhibiting API crystallization. ( X`I%&/m{JJt`$@iG#)*eVe]f@{{;N'?\fdlJ!?~|? Description:Chemical PropertiesMicrocrystalline cellulose is a purified, partially depolymerized cellulose that occurs as a white, odorless, tasteless, crystalline powder composed of porous particles. The formed cellulose molecules pack themselves closely to each other, stabilised through hydrogen bonds, creating crystalline regions interspersed with amorphous regions. Aquacoat ECD is an aqueous dispersion of ethylcellulose used for sustained release barrier or slow release pharmaceutical coating, moisture barrier and taste masking applications for tablet and multi-particulate dosage forms. They are made up of sulfated and non-sulfated repeating units of galactose and 3,6-anhydrogalactose. X\o^ Cellulose, microcrystalline | C14H26O11 | CID 14055602 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . This grade of polymer film remains intact at pH< 6, thus protecting the API in gastric environments. Microcrystalline cellulose has excellent compressibility properties and is widely used in solid forms such as tablets that are hard, but can dissolve quickly, and this has increased its demand in . The charts below provide guidance on how to select and use standard and co-processed grades of Avicel Microcrystalline cellulose in pharmaceutical products. Chemical Formula: (C6H10O5)n 1.4. Chemically, it is an inert substance, is not degraded during digestion and has no appreciable absorption. In roller compaction, Avicel Microcrystalline cellulose improves compaction during the ribbon phase, enabling a trouble-free process while also preserving the plasticity of the compacts. Microcrystalline Cellulose / Avicel PH-102. These grades have particle sizes ranging from <30 to approximately 200. The chemical structure of cellulose is shown below: In the biosynthesis of cellulose, two molecules of -D-glucose molecules combine via a condensation reaction (elimination of one molecule of water) to form the so-called cellobiose unit. Learn about our new global sustainability platform, Learn about FMC's industry leading goal of net-zero emissions by 2035, Learn about FMC's differentiated biologically-based crop solutions. Combines good flow and high compactibility. Avicel Microcrystalline cellulose is composed of insoluble fibre and does not contribute any other material of nutritional importance. This paper is based on a study of the interactions that take place during the process of hydrogel formation, break down, and recovery. 0.25 - 0.37. Eur., JPE . A family of polysaccharide products that allow distinctive drug delivery solutions. /Producer(Sub Systems, Inc.)/CreationDate(D:20181207095625+05'00')/ModDate(D:20181207095625+05'00')/Creator(Sub Systems, Inc.)
Description: Microcrystalline Cellulose E460 is a term for refined wood pulp manufactured through plant fibre hydrolysis. Avicel Microcrystalline cellulose is available in many grades, which differ in particle size, bulk density, and moisture content. The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. EMCOCEL XLM 90. (Microcrystalline Cellulose Market Pr. msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, X]s
;/4'OslUK:|QY`IL|w @ I!*2T~IN?*}y2*49]yOQ*VG%Gu,;&9zE{q==xvrv}rd(yG*qN6E0K$IBWhe Material safety data sheet (MSDS) of the m icrocrystalline cellu lose (MCC) Thus, Avicel contributes no or very few calories to the food system. Carboxymethyl Cellulose Sodium N/A Nutrition & Biosciences www.pharma.dupont.com HO 00017 - 0 E L 02.2020 www.dupontnutritionandbiosciences.com . Regulatory Information stream However, if handling bulk powders, observance of appropriate safeguards is recommended. Test Data Available. The fumarate moiety of Alubra increases its melting temperature, which allows for greater functionality at high press speeds while the stearate chain maintains the lubricity of the compound and supports low ejection forces. In Cellulose and Cellulose Derivatives in the Food Industry, T. Wstenberg (Ed. Earth Supplied Products LLC. Similarly, the European Food Safety Agency has also evaluated Microcrystalline cellulose and established that it is not absorbed systemically and excreted unchanged. Avicel is one of the best-known pharmaceutical excipient brands and, without doubt, one of the most frequently used raw materials in solid oral product formulation and manufacture. United Nations Sustainable Development Goals, Alginates Protanal, Manucol, Protacid and More, Barrier membrane, Controlled release hydrophilic matrix, Taste masking, Carrageenan Gelcarin, Viscarin and More, Controlled release hydrophilic matrix, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Rheology modifier, Rheology modifier/stabilizer, Binder, Controlled release hydrophilic matrix, Rheology modifier, Rheology modifier/stabilizer, Shell - hard capsule, Tablet coatings, Thin films, Topical, Capsules, Other, Solutions, Suspensions, Tablets, Controlled release hydrophilic matrix, Hot melt extrusion, Muco-adhesive, Osmotic pump, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Topical. Aqueous suspensions of microcrystalline cellulose have . vdZ@Rgl{eU+7N!3!|hUmW)~}U*7k i@j)q["MEydtP"ftFu]t }JN~A"8lz7#}J.i@
qaj/QU<5OrVMfl{pL? This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication. LOT #: Available upon request. We are artists at heart and creators by nature. Alginates also function as actives in some anti-reflux products. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? q9;v80q>jZ Molecular weight: Not Applicable 1.5. More sophisticated drug discovery techniques have led to pipeline compounds that require solubility enhancement to be therapeutically effective. The short-term limit for total inhalable dust is 20 mg/m3. cas:9000-11-7 msds Carboxymethyl cellulose. This Microcrystalline Cellulose . Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 April 21st, 2019 - Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 Section 1 Chemical Product and Company Identification Ethanol has been shown to produce fetotoxicity in the embry o or fetus of laboratory animals Prenatal Chemical waste generators must determine . Manufactured by: China . Avicel Microcrystalline cellulose occurs as a white, odourless, tasteless, fibrous powder composed of porous particles. ]c\RbKSTQ C''Q6.6QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ p@" JRS Pharma: PROSOLV SMCC 90: Microcrystalline Cellulose, Colloidal Silicon Dioxide: 125: 0.25 - 0.37: Formulas in which a balance of flow and compaction is required. /Type/Page
Microcrystalline cellulose (MCC) is a pure partially depolymerized cellulose synthesized from -cellulose precursor (type I), obtained as a pulp from fibrous plant material, with mineral acids using hydrochloric acid to reduce the degree of polymerization. Avicel Microcrystalline Cellulose: A Guide to Grades and Uses, Working Hours (Mon to Friday): 08:30 - 17:30, legendary Canadian-born chemist, Orlando Aloysius Battista, United States Pharmacopoeia and National Formulary, United States Food and Drug Administration, Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g), https://doi.org/10.1016/0378-5173(95)04231-8, https://doi.org/10.1016/j.ejpb.2004.05.009, https://doi.org/10.1002/9783527682935.ch04, Pharmaceutical Acronyms and Abbreviations, Glossary of Terms Used in the Pharmaceutical Industry, Standard Terms & Conditions Of Sale Of Goods And Services, 4-O-[(1S)-hexopyranosyl]-D-glycero-hexopyranose. A schematic illustration of the manufacturing process for Avicel Microcrystalline cellulose is shown below. on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. The application areas for Avicel Microcrystalline cellulose are immense and encompass many industrial sectors such as food, pharmaceuticals, and cosmetics. Some substance identifiers may have been claimed confidential, or may . The polymers added organosolubility further creates advantages for employing HPMC in solvent spray-drying applications. Fiber supplements can lessen the absorption of some . If you are already a ChemPoint customer then sign up for access to our online ordering website. Avicel co-processed grades are co-spray dried blends of Avicel microcrystalline cellulose with synergistic pharmaceutical excipients to yield functional benefits beyond simple physical blends. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. Go to Investor Relations. Its used in capsules and tablets, both in wet granulation and direct compression processes, where it serves as a moisture adsorbent, tablet, and capsule diluent, and tablet disintegrant.It is also widely used as a supplementary formulation aid, primarily to enhance the . They are soluble in a wide range of organic solvents, beginning with aliphatic alcohols such as ethanol and isopropanol, and are compatible with most other familiar organic solvent chemistries, including ether alcohols, ketones, aromatic hydrocarbons and many more. <>
Of all the different brands and grades of MCC, Avicel PH 101 or Emcocel 50 has been the most widely used. Formulators select it when they need to enhance a formulations robustness especially when less compactable diluents and binders are used. It does not interfere with other nutrients when added to food products, and is instead, an excellent carrier and stabiliser, helping prolong the viability of food products. Cellulose microcrystalline. This unique functionality can be used in a diversity of applications such as controlled release dosage forms, enteric coatings, microencapsulation and stabilization in solutions and suspensions. It . ( Product Name Cellulose microcrystalline. : 5 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Standard, 29 CFR 1910.1200 and Canadas Workplace Hazardous Materials Information System (WHMIS) requirements. MCC helps in the formation of spheres because of its . endstream
Truly distinctive drug delivery solutions. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. 8 0 obj Material Safety Data Sheet or SDS for Cellulose microcrystalline 102331 from Merck for download or viewing in the browser. {ddn(Y?I#K-}t|l #:FHF'D)/)"{k\pM
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WQC}>e|Gs_Q'+mB| X{URv/Z'` 4w'8sC~ cON&pIk:F/Q&u~.S{"% pg:lfx -. Instead, they obtained a stable colloidal suspension. For this reason, nutritionists regard standard powdered microcrystalline cellulose as having zero energy content. Molecular Weight null. }[eD-1-8$#Yi^$o8Nc6vwfw;wBT~[Rgi1?%T*/J:/'+Gf'Ae*j@{Rh+2oN|Sbtt;z#v8})F#z=:*]q+U>+ .e
^Q-{@ RPC t/(If>8P&%wNPMJw,VI2aUqRqe3bC,a;C&4RQSf*(=I$r{'%jmk1LUZV(*is6r&wQPAAoID4p?,"lp:wE+)v(_w
'yelVnMh=gIYjK:9v{$G;b8=lGG1_,h^0F2`a~Kusz1p#NS*qt6,F:7+Rma-4u} DINFzJ"Mlctg*~HEge All Rights Reserved. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Avicel co-processed products are high functionality excipients offering improved powder flow, granule properties, tablet compression, and mouth feel. 2 0 obj
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Origin(s): Plant/Botanical. The table below lists the most important chemical identifiers applicable to Avicel Microcrystalline cellulose. Explore how you can develop your career and bring your creative ideas to life at IFF. Alubra is also less susceptible to over-blending contributing to more flexible process conditions and reduced waste due to over blended batch failures. CAS No. pH 6.0 to 8.0 . When selected in wet granulation, the optimum level of use is between 5 and 20%, although higher levels have been successfully used. Gloves, eye protection and a dust mask should be used. : 9004-34-6 1.2 Relevant identified uses of the substance or mixture and uses advised against Hi, let us know if you have any questions as you visit our website. METHOCEL products have been in continuous production for more than 70 years with production facilities and deep product expertise located around the globe. CAS #: 9004-34-6 1.6. /Resources 2 0 R
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};khd5x=fr SUBSTANCE IDENTIFICATION 1.1. XiDqLN MD'F2`jI7ZWu,JK%5e9~:R>LAm\WyY0lk=ZNP;pZ23)P0GG~%e[ d8GIXRo&. Explore how we work and why we apply science and creativity for a better world to everything we do. Microcrystalline Cellulose NF. 1. Avicel Microcrystalline Cellulose is a safe and non-hazardous material that is widely used in pharmaceutical formulations and food products (as a bulking agent and to add crispness). PDF (4.11 mb) Footer menu 1. The product would later go on to be commercialized under the brand name Avicel by FMC Corporation. It is also inert and biocompatible. POLYOX resins are nonionic polyethylene oxide solubility polymers. No: 9004-34-6-5 Version: Global Date Approved: 10/16/1998 . Avicel Microcrystalline cellulose is a type of cellulose, a naturally-occurring, large molecular weight polysaccharide found in woody plants. %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz Chemical Formula: (C6H10O5)n 1.4. Delivering efficient and robust formulations. cas:9004-36-8 msds CELLULOSE ACETATE BUTYRATE. Our customers around the world enjoy the benefits of TEXTURECEL NaCMC in various wound care products, too. G2W4de=u183KGH{ vQ#4:1\wc Researcher's newest research report, the "Wood Pulp Based Microcrystalline Cellulose Industry Forecast" looks at past sales and reviews total world Wood Pulp Based Microcrystalline Cellulose sales in 2022, providing a comprehensive analysis by region and market sector of . II: effects of changes in the content of Microcrystalline Cellulose, AAPS PharmSci, 2 (2000) 45. The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. Watch Now. An agricultural sciences company. This extends the funcionality of microcrystalline cellulose to meet specific viscosity, gelling, suspension and stabilizing properties ChemPoint is an approved supplier of LATTICE MCC in industrial applications, providing dedicated marketing, sales, order fulfillment, and technical support for customers in the EMEA region, Protect and improve AI potency, entrap oil droplets and improve stability, physical barrier that helps suspend particles and breaks down under shear and reforms quickly under rest. Pharmacel 112 is a directly compressible microcrystalline cellulose grade with a low moisture content (LOD Max. Looking for FMC'searnings news? % TEXTURECEL is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades. !,K`I[O@U|$+i 8sB|+"B@'2^7[2XKrd#5b Medium size standard MCC grade, suited for the majority of directly compressible actives. : 160182. \C[i+rY2$V,,WT#_)3K?=/fW%[,lE"V?C
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g(*Rrm0gyv9i@0UT:A+{eW/y BS3_!Qv rt^BN! In the late 1960s, Avicel Microcrystalline cellulose was registered in the supplement to the National Formulary as a pharmaceutical excipient. They are differentiated from each other by the amount of 3,6-anhydrogalactose as well as the number and position of ester sulfate groups present. (&E. stream
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Avicel PC 611 (FMC Biopolymer) Supplied by. Avicel is a brand name by Dupont for grades of Microcrystalline cellulose. iq/iVO"5VI}dn.#q^(fJ),BN
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!(!0*21/*.-4;K@48G9-.BYBGNPTUT3? The typical mean particle size is 20200 m. The process is relatively basic; and starts with treating cellulose, obtained as a high-grade pulp obtained from fibrous plant material, with mineral acids, followed by purification and spray-drying. However, it yields non-digestible fibre. This is unlikely to be a problem when Microcrystalline cellulose is consumed as part of a medical product where it is used as an excipient in the formulation. %PDF-1.5
Microcrystalline Cellulose. /Producer(Sub Systems, Inc.)/CreationDate(D:20211228124915+05'00')/ModDate(D:20211228124915+05'00')/Creator(Sub Systems, Inc.)
Learn about FMC's differentiated biologically-based crop solutions. FMC Corporation: Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations DE102009022738A1 (de) * 2009-05-26: 2010-12-09: J. Rettenmaier & Shne Gmbh + Co. Kg . The 'Substance identity' section is calculated from substance identification information from all ECHA databases. Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 C for 15 min. lH5JWy}DgKRR"Fs It is . Safety Data Sheet (SDS) Viewer. Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives. Product Name: Microcrystalline Cellulose 1.2. endobj
Revision No. F. Steele, M. Tobyn, S. Edge, A. Chen & J. N. Staniforth.Physicochemical and Mechanical Evaluation of a Novel High Density Grade of Silicified Microcrystalline Cellulose, Drug Development and Industrial Pharmacy, 30:1 (2004), 103-109. Fmc Corporation: Ultra-fine microcrystalline cellulose compositions and process . AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. To help, weve put together a simple guide for selecting Avicel Microcrystalline cellulose grades, with simple explanations of some of the most common grades, plus recommendations that will serve the majority of buyers. stream
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No. The table below lists the typical nutritional information of microcrystalline cellulose: Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g)1. } !1AQa"q2#BR$3br 4 0 obj
Dupont acquired the microcrystalline cellulose business of FMC Corporation in 2017. . GRINDSTED Xanthan Gum is a naturally fermented product of carbohydrates and is applied in various liquid, semi-solid and solid pharmaceutical dosage forms. Apply today! MSDS Ref. }o]X4]. cas:9032-51-3 msds CELLULOSE PAB. Microcrystalline cellulose in certain fiber supplements may cause mild side effects ().These may include gas, bloating and increased stool production.. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. It should be noted that native cellulose itself is completely indigestible, and its hydrolysis during the production of microcrystalline cellulose does not alter its behaviour in the intestine. In extrusion-spheronisation, it is the excipient of choice. <<
Description: Microcrystalline Cellulose is a term for refined wood pulp manufactured through plant fibre hydrolysis. : 9004-34-6 Date Approved: 01/31/2008 . Avicel Microcrystalline Cellulose: Chemical Identifiers. Superior Performance: Provides excellent water uptake and rapid swelling . Co-processed excipients deliver functional synergies to address formulation challenges with simplified, single ingredient solutions. Microcrystalline cellulose 9004-34-6 232-674-9 Not Listed * Magnesium stearate 557-04- 209-150-3 Not Listed * It is, however, a good source of fibre. PROSOLV SMCC, silicified microcrystalline cellulose, is a unique combination of microcrystalline cellulose (MCC) and colloidal silicon dioxide (CSD).A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation. xv}O2' H~KEe9>G/,:9\i Heavy metals, % NMT 0.001 MATERIAL SAFETY DATA SHEET Avicel PC 611 Microcrystalline Cellulose Page 1 of 8 MSDS Ref. DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 . Performing this action will revert the following features to their default settings: Hooray! If you have Crohn's disease or a history of bowel obstruction, discuss with a doctor or pharmacist about drug interactions with fiber supplements.. 10.1 Future Forecast of the Global Microcrystalline Cellulose Market from 2023-2028 Segment by Region 10.2 Global Microcrystalline Cellulose Production and Growth Rate Forecast by Type (2023-2028 . microcrystalline cellulose and carboxymethylcellulose sodium NF, Ph. Cellulose microcrystalline Revision Date 25-Dec-2021 SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA - Occupational Safety and Health Administration Not applicable CERCLA Not applicable California Proposition 65 This product contains the following Proposition 65 chemicals. Carrageenan is a naturally occurring family of hydrophilic polysaccharides extracted from several closely related species of red seaweeds. 4 0 obj
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These include amphiphilicity, a higher degree of crystallinity, surface area, higher hydration properties, and morphology. endobj
CAS 9004-34-6, pH 5 - 7.5. gac74
[#B6`Wnw7 Microcrystalline cellulose (C6H10O5)n is refined wood pulp. INCI. It is hygroscopic and insoluble in water. Chemical Name Microcrystalline cellulose (INCI Name): MCC, cellulose gel Common Name Avicel PH105 Microcrystalline Cellulose CAS Number 9004-34-6 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice No data available If Inhaled Remove person to fresh air. However, consumption of large quantities of the material may have a laxative effect. There may be more fiber in your food than you realized. AVICEL RC 581. Unique functionality for a broad range of pharmaceutical applications. Dyvo5bp#bR W7~IF C"
d6zLz~!#>@HO}sx;hm>> Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named 'mechanically disintegrated D.P cellulose. Microcrystalline cellulose is a commonly used excipient in the . : 160182 Date Approved: 05/25/2010 Revision No. Material Safety Data Sheet TALSTAR S INSECTICIDE Version 1 Page 1 / 8 SDS # : 6320-A This MSDS has been prepared to meet U.S. OSHA Hazard Communication Standard 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS) requirements. To overcome the pitfalls of known overlays, we tested suspensions of microcrystalline cellulose Avicel RC/CLtrade mark as overlay media in the plaque and plaque-inhibition assay of influenza viruses. JFIF ` ` ZExif MM * J Q Q Q C
Micro Crystalline Cellulose. As some of the data above show, microcrystalline cellulose possesses unique physicochemical properties that set it apart from native cellulose. Avicel Microcrystalline cellulose also serves as a moisture adsorbent and as a general-purpose formulation improver.
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